Last update: July 2015
The eMERGE-PGx project was a multi-center pilot of implementing pharmacogenetic sequencing in clinical practice to improve health care. SPHINX is a searchable catalog of observed inherited variants in a 9015 subject population, large enough to reflect even rare variation. The participants’ constitutional DNA was sequenced using the PGRNseq assay, a targeted megabase of sequence in 82 PGx genes, genes identified as important for pharmcogenomics.
What Can I Do with SPHINX?
See the lists of genes, drugs, and pathways in the catalog
Search the catalog of variants by:
See for each gene:
See for each variant:
The sites participating in eMERGE and the eMERGE-PGx project include:
Manuscripts should cite the following grants:
The eMERGE Network was initiated and funded by NHGRI through the following grants: U01HG006828 (Cincinnati Children’s Hospital Medical Center/Boston Children’s Hospital); U01HG006830 (Children’s Hospital of Philadelphia); U01HG006389 (Essentia Institute of Rural Health, Marshfield Clinic Research Foundation and Pennsylvania State University); U01HG006382 (Geisinger Clinic); U01HG006375 (Group Health Cooperative/University of Washington); U01HG006379 (Mayo Clinic); U01HG006380 (Icahn School of Medicine at Mount Sinai); U01HG006388 (Northwestern University); U01HG006378 (Vanderbilt University Medical Center); U01HG006385 (Vanderbilt University Medical Center serving as the Coordinating Center); and U01HG004438 (CIDR) serving as a Sequencing Center.