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The sites participating in eMERGE and the eMERGE-PGx project include:
  • Children's Hospital of Pennsylvania
  • Cincinnati Children's Medical Center with Boston Children's Hospital
  • Essentia Rural Health with Marshfield Clinic and The Pennsylvania State University
  • Geisinger Health System
  • Group Health Cooperative with University of Washington
  • Mayo Clinic
  • Mount Sinai School of Medicine
  • Northwestern University
  • Vanderbilt University

SPHINX is a web-based tool for exploring drug response implications of genetic variation across the eMERGE PGx project cohort.

The eMERGE-PGx project is a multi-center pilot of pharmacogenetic sequencing in clinical practice. Once fully enrolled, SPHINX will contain data on nearly 9000 subjects from participating electronic medical record (EMR) systems. PGRN-Seq sequencing will identify common variants, some with known clinical implications, and also variants of unknown significance. SPHINX has a public-facing gene variant repository that provides variant summary data.

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